In-vivo Studies

MeKo conducts in-vivo studies for animal experiments in renowned laboratories:

• Favorable in-vivo results for Resoloy® coronary scaffolds
• Ex-vivo degradation analysis using computed tomography and SEM/EDS
• OCT/QCA analysis
• Synchrotron examination

Degradation Testing Laboratories

MeKo conducts in-vitro degradation tests for Mg scaffolds:

• Simulated blood circulation
• Controlled flow rate, pressure, pulsation, and temperature of circulation
• Blood substitute solution for standardized tests: PBS, SBF, ...
• Fast and reproducible degradation evaluation
• Monitoring and visualization of the degradation process
• Prediction of in-vivo degradation behavior

Functionality of Magnesium Alloy Resoloy®

Extensive in-vitro and in-vivo tests have been conducted for a scientific study on the degradation of vascular scaffolds (bioresorbable stents) made from the magnesium alloy Resoloy®. The results confirm that the degradation time of Resoloy® can be adjusted thanks to a double coating with fluoride and polymers. A significantly slower degradation is achieved in-vitro compared to Magmaris®. Another advantage is that Resoloy® degrades without residues. Animal experiments confirm the in-vitro results from the test laboratory and show that Resoloy® is highly biocompatible. The results of the published study demonstrate the high level of safety and efficacy of the alloy.