RESOLOY®
The resorbable magnesium
alloy for scaffolds
MeKo - competence in contract manufacturing
of stents and vascular implants
With Resoloy® MeKo offers a bioresorbable magnesium-alloy with extraordinary properties. Resoloy® is an attractive alternative to polymer scaffolds. In comparison to PLLA, it offers about 3 times higher strength, thinner struts, a higher radial force and is applicable for direct stenting. The degradation time of Resoloy® is adjusted by coatings. It has a proven biocompatibility, no shelf life and no temperature issues.
Properties of RESOLOY®
- a bioresorbable
- „leaving nothing behind“
- biocompatible
- adjustable degradation time and mechanical properties
- MRI compatible
MeKo capabilities for Mg-scaffolds
- laser cutting
- electro polishing
- heat treatment
- coatings for degradation adjustment
- X-ray marker
- degradation testing
- support for scaffold registration
Resoloy® Coatings
Tubing in stock
Ø 1,80 mm x 0,160 mm (Ø 0.071“ x 0.0063“)
Ø 2,20 mm x 0,160 mm (Ø 0.087“ x 0.0063“)
Ø 3,15 mm x 0,215 mm (Ø 0.124“ x 0.0085“)
Other tubing dimensions upon request.
Ø 2,20 mm x 0,160 mm (Ø 0.087“ x 0.0063“)
Ø 3,15 mm x 0,215 mm (Ø 0.124“ x 0.0085“)
Other tubing dimensions upon request.
In-vivo studies
MeKo performs in-vivo studies for animal trials in renowned labs:
- favorable in vivo results for Resoloy® coronary-scaffolds
- degradation analysis ex-vivo with computed tomography and SEM/EDS
- OCT/QCA analysis
- Synchrotron investigation
Degradation Test Lab
MeKo performs in-vitro degradation tests for Mg-scaffolds:
- simulated blood circulation
- controlled flow rate, pressure, pulsation and temperature of circulation
- blood substitute solution for standardized tests: PBS, SBF, ...
- accelerated in-vitro degradation tests
- fast and reproducible evaluation of degradation
- monitoring and visualization of degradation process
- prediction of in-vivo degradation behavior
Resoloy® Fabrication Process
Study Confirms Functionality of the Magnesium Alloy RESOLOY®
Extensive in vitro and in vivo tests have been performed for a scientific study on the degradation of vascular scaffolds (bioresorbable stents) made from the RESOLOY® magnesium alloy.
The results confirm that the degradation time of RESOLOY® can be adjusted thanks to a double coating of fluoride and polymers. A significantly slower degradation is achieved in vitro compared to the Magmaris®.
An additional advantage is that RESOLOY® degrades with no residue. The animal tests confirm the in vitro results from the test laboratory and demonstrate that RESOLOY® is highly biocompatible. The results of the published study demonstrate the high degree of safety and efficacy of the alloy.
Questions & Answers
What is the current lead time for a Resoloy® scaffold?
If MeKo has the material in stock, the normal lead time is about 4-6 weeks. There is always the possibility of an accelerated production reducing the lead time to about 10 days.
What is the smallest achievable tubing OD for now?
Is it possible to buy the material on its own?
Are there any stents or products made of Resoloy® currently on the market?
Is Resoloy® meant to be self-expandable or balloon-expandable?
What is the degradation rate of Resoloy® in vivo?
It looks like some struts migrate during the degradation testing video. Is embolization an issue in vivo or are the broken struts "embedded" in new tissue?
Is the ingrowth of tissue faster than the degradation?
What type of coatings can you provide?